Sympathetic Nerve Activity in End-Stage Renal Disease

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Sympathetic nerve activity in end-stage renal disease.

BACKGROUND Uremia is proposed to increase sympathetic nerve activity (SNA) in hemodialysis patients. The aims of the present study were to determine whether reversal of uremia by successful kidney transplantation (RTX) eliminates the increased SNA and whether signals arising in the diseased kidneys contribute to the increased SNA in renal failure. METHODS AND RESULTS We compared muscle sympat...

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End-stage renal disease (ESRD) is characterized by resting sympathetic overactivity. Baseline muscle sympathetic nerve activity (MSNA), which is governed by baroreflexes and chemoreflexes, is elevated in ESRD. Whether resting skin sympathetic nerve activity (SSNA), which is independent from baroreflex and chemoreflex control, is also elevated has never been reported in renal failure. The purpos...

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ژورنال

عنوان ژورنال: Circulation

سال: 2002

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.0000034043.16664.96